池 岛 乔 (Takshi Ikejima)
性别：男
出生年月：1947年9月
籍贯：日本东京都
出生地：日本冈山市
技术职称：教授/所长　博士生导师
工作单位：沈阳药科大学中日医药研究所（沈阳）
使用语言：汉语，英语，日语

学历：
1972年3月 日本东北大学理学部生物学科毕业
1972年4月 日本东北大学研究生院理学研究科硕士入学
1974年4月 日本东北大学研究生院理学研究科博士入学
1978年3月　理学博士

工作经历：
1977年11月 横滨市立大学医学部第一解剖学教研室助教
1980年7月 (美国)Harvard(哈佛)大学医学院客座副教授
1982年9月 Tufts大学(美国Boston市)医学院实验医学部研究员
1983年7月 Tufts大学医学院实验医学部讲师
1986年7月 Tufts大学医学院地域医学及感染症部副教授
1992年4月 日本万有制药株式会社(美国Merck公司分公司)分子生物学研究所、细胞生化学研究部长
1996年6月 兼任日本国立予防卫生研究所(现国立感染症研究所)客座研究员
1996年7月 长春中医学院中日联合研究室客座教授
（教授免疫学药理学、细胞学、分子生物学）
1998年4月 哈尔滨医科大学顾问教授
1998年12月 暨南大学(广州)客座教授
2001年6月　长春中医学院附属医院中日医学研究所所长教授
2002年2月　沈阳药科大学中日医药研究所所长教授
2002年4月　沈阳药科大学博士生导师
2002年11月 辽宁中医学院客座教授
2003年4月 广州中医药大学客座教授
2004年1月 日本皮革研究所客座研究员
学位、外语水平
1978年3月 　 理学博士 （日本东北大学第550号）
1981年3月 　 英语高级（美国Harvard University　哈佛大学）
1994年7月　　汉语测试合格(日本汉语测试协会)

研究方向：
选用天然产物的精制单体化合物，即吴茱萸碱（evodiamine）、冬凌草甲素（oridonin）、及其它由沈阳药科大学提取精制的天然药物单体等为诱导剂，研究其药理作用机制，在分子水平上寻找这些药物作用的新靶点, 建立药物筛选模型，开发新型抗癌、抗衰老药物。研究水飞蓟素（silymarin）等具有抗衰老药理作用的天然药物单体对各种病理生理刺激诱导凋亡的细胞的影响，筛选出具有抗凋亡活性的药物单体，研究其作用机制，为开发抗衰老药物奠定基础。在研究过程中，我们发现天然产物单体不仅起到诱导（拮抗）凋亡，同时还能诱导癌细胞吞噬（自噬），以及诱导癌细胞老化等作用。本研究小组目的在于从分子生物学、生物化学及免疫学等方面阐明这些中药单体对细胞膜、细胞质、及细胞核内生物活性物质的药理学作用，寻找新的药物作用靶点。阐明炎症，凋亡，自噬，衰老之间的相互关系，以开发新型具有抗炎、抗癌、抗衰老作用的新药。

［获奖情况］
吉林省长春市：白求恩工作者
吉林省：优秀外国专家
辽宁省沈阳市：玫瑰奖
辽宁省：友谊奖

[学会会员]
日本药理学会
日本药学会
日本免疫学会
日本和汉医药学会
日本临床中医药学会（理事）
日本未病系统学会（评议员）

［研究生培养］
已毕业中国硕士生10人，博士生11人（沈阳药科大学，吉林大学，长春中医药大学）；
现有在校硕士生9人，博士生9人。

[联系方式]
联系地址：辽宁省沈阳市文化路103号，沈阳药科大学中日医药研究所
邮编：110016
联系电话：（办公室）024-23844463 或　（实验室）024-23986973
传真：024-23844463
手机：13840143597
E-mail: ikejimat@vip.sina.com (汉语，英语，日语)

2002至2007年发表

学术论文

• T. Ikejima and T. Takeuchi. Genetic Modification of the molecular forms of tyrosinase in the house mouse. Jpn. J. Genetics, 49:37-43, 1973.
• Yuji Sugita, T. Ikejima and T. Takeuchi. Studies on the expression of genes for melanogenesis in vivo and in vitro. Proc. Ixth Internat. Conference: 177-183, 1976
• T. Ikejima and T. Takeuchi. Fluorescencespectrophotometrical analysis of melanins in the house mouse. Biochem. Genetics, 16:673-687, 1978.
• T. Ikejima and T. Takeuchi. Environmental control of gene expression in the mouse pigmentation. Jpn. J. Genetics, 55:283-287, 1980.
• T. Ikejima and S. Ito. Carbonic anhydrase in mouse parotid glands:Histological, immunological and biological analysis. J. Histochem. Cytochem. 36:625-635, 1984.
• T. Ikejima, C.A. Dinarello, D.M. Gill and S.M. Wolff. Induction of interleukin-1 by a product of Staphylococcus aureus associated with toxic shock syndrome. J. Clin. Invest. 73:1312-1320, 1984.
• A. Hirose-Kumagai, F.H. Whipple, T. Ikejima, C.A. Dinarello, D.M. Gill, H.L. Ritz and G.G. Bond. A comparison of neutralizing and antigen-binding assays for human antibodies against toxic shock toxin. J. Infect. Dis. 150:788, 1984.
• A. Hirose-Kumagai, T. Ikejima and D.M. Gill. Established macrophage-like cell lines synthesize interleukin-1 in response to toxic shock toxin. Infect.Immun. 50:765-769, 1985.
• 池岛乔,C.A. Dinarello.细胞因子（主要是IL-1）的病理生理学。 日本临床免疫学会会志第9卷：333-336, 1986.
• C.A. Dinarello, T. Ikejima, S.J.C. Warner, S.F. Orencole, G. Lonneman, J.G. Cannon and P. Libby. Interleukin-1 in rabbits in vivo and in human mononuclear cells in vitro. J. Immunol. 139:1902-1910, 1987.
• J.W.M. van der Meer, S. Endres, G. Lonneman, J.G. Cannon, T. Ikejima, S. Okusawa, J.A. Gelfand and C.A. Dinarello. Concentrations of immunoreactive human tumor necrosis factor alpha produced by human mononuclear cells in vitro. J. Leukocyte Biol. 43:216-223, 1988.
• S. Okusawa, J.F. Gelfand, T. Ikejima, R.J. Connolly and C.A. Dinarello. Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J. Clin. Invest. 81:1162-1172, 1988.
• T. Ikejima, S. Okusawa, J.W.M. van der Meer and C.A. Dinarello. Tumor necrosis factor-like substance in rabbits and immunoreactive tumor necrosis factor and interleukin-1 from mononuclear cells. J. Infect. Dis. 158:1017-1025, 1988.
• 池岛乔、IL-1与免疫应答。Annual Review免疫1988:157-167、1988.
• T. Ikejima, S. Okusawa, J.W.M. van der Meer and C.A. Dinarello. TSST-1 resistance in mice is mediated by interleukin 1 and tumor necrosis factor. Rev. Infect. Dis. 11 suppl. 1:S316-317, 1989.
• T. Ikejima, S.F. Orencole, S.J.C. Warner and C.A. Dinarello. TSST-1 resistance in mice is related to interleukin 1 production by TSST-1. Rev. Infect. Dis. 11 suppl. 1:S330, 1989.
• L.I. Rumero, T. Ikejima and S. Pincus. In situ localization of interleukin-1 in normal and psoriatic skin. J. Invest. Derm. 93:518-522, 1989.
• N. Savage, A.J. Puren, S.F. Orencole, T. Ikejima, B.D. Clark and C.A. Dinarello. Studies on IL-1 receptors on D10S helper cells: Demonstration of two molecularly and antigenically distinct IL-1 binding proteins. Cytokine 1:23-35, 1989.
• T. Ikejima, S. Okusawa, P.Ghezzi, J.W.M. van der Meer and C.A.Dinarello. Interleukin-1 induces tumor necrosis factor from mononuclear cells in vitro and circulating TNF-like activity in vivo. J. Infect. Dis. 162:215-223, 1990.
• C.A. Dinarello, B.D. Clark, T. Ikejima, A. Puren, N. Savage and P.M. Rosoff. Interleukin-1 receptors and biological responses. Yale J. Biol. Med.:87-93, 1990.
• B.D. Clark, T.Ikejima, J. Mancilla, S.P. Sirko, S.F. Orencole, N. Ishii, K.Okuda, and C.A. Dinarello. An antibody to a 17 amino acid synthetic peptide of the 80kDa IL-1R blocks IL-1 binding to its receptor. Molecular and Cellular Biology of Cytokines, Alan R. Liss, Ed., New York, 1991.
• J. Mancilla, T. Ikejima, and C.A. Dinarello. Glycosylation of the interleukin-1 receptor type I is required for optimal binding of interleukin-1. Lymphokine and Cytokine Research 11:197-205, 1992.
• 池岛乔、内毒素与毒素的休克综合症引起的炎症性细胞因子的诱导。Cell Science 8:1-7, 1992.
• 池岛乔、巨噬细胞释放产生的中间转导因子与生理反应。―IL-1引起的炎症诱导机制为中心。Medical Immunology 26:67-74, 1993.
• 福生吉裕、永岛干夫、本田治久、小林阳治、赫章郎、深田めぐみ、池岛乔、HMG-CoA还原酶抑制剂(Simvastatin)对细胞因子产生的影响。动脉硬化22卷23号：221-226,1994.
• F. Fukuo, M. Nagashima, N. Soya-Ohmura, S. Takagi, A. Terashi and T. Ikejima, Effects of an HMG-CoA reductase inhibitor on cytokine production by human monocyte/macrophages. 日本医科大学杂志64 :386-390, 1995.
• K. Torigoe, N. Wakasugi, N. Sakaizumi, T. Ikejima, H. Suzuki, K. Kojiri and H. Suda. BE-40644, a new human thioredoxin system inhibitor isolated from Actinoplanes sp. A40644. Ｊ．Antibiotics 49:314-317, 1996.
• 池岛乔、疼痛与炎症的分子机制与控制—以炎症因子为中心。 嘌呤与嘧啶的代谢（日本）第20卷：107－111，1996.
• B.D. Clark, T. Ikejima, J. Mancilla, S.P. Sirko, S.F. Orencole, N. Ishii, K. Okuda, and C.A. Dinarello. An antibody to a 17 amino acid synthetic peptide of the type I interleukin-1 receptor preferentially blocks interleukin-1 binding. J. Interferon and Cytokine Res. 16(12)：1079-1088, 1996.
• Takeuchi, H. Ohhashi, P.J. Birckbicheler and T. Ikejima. Nuclear translocation of tissue type transglutaminase during sphingosine-induced cell death:A novel aspect of the enzyme with DNA hydrolytic activity. Zeitschrift fur Naturforschung 55C：352-358, 1998.
• 池岛乔，朴志贤，郭颖杰，王毅，王本祥， 蜂毒对炎症性细胞因子产生的影响。 中国药理与临床 14: 26, 1998.
• 王毅，刘铁汉，王本祥，池岛乔，人参皂甙Rg1的肠内代谢及其他代谢产物对细胞因子的影响。中国药理与临床 14: 42, 1998.
• 郭颖杰，朴志贤，王本祥，刘永强，池岛乔， 黄芪对人细胞因子产生的影响。中国药理与临床 14: 42, 1998.
• 王本祥，刘铁汉，永田年，池岛乔， 人参皂甙Rg1的肠内代谢研究（III）-人参皂甙Rg1及其他代谢产物免疫活性的研究。 中国基础医学杂志5:10, 1999。
• 王本祥，王毅，郭颖杰，南陆彦，刘铁汉，吴立军，永田年，池岛乔， 淫羊霍甙的场菌代谢研究（II）-淫羊霍甙及其肠菌代谢产物对THP-1细胞分泌细胞因子的影响。中国基础医学杂志5:11-14, 1999。
• A. Ito, A. Plancarte, M．Nakao,　K．Nakaya， T. Ikejima, ZX. Piao, T. Kanazawa　and SS. Margono. ELISA and immunoblot using purified aglycoproteins forf serodiagnosis of cysticercosis in pigs naturally infected with Taenia solium. J. Helminthol. 73:363‐5，1999.
• 刘铁汉，王本祥，王毅，郭颖杰，吴立军，南陆彦，永田年，池岛乔， 淫羊霍苷的肠菌代谢研究（II）：淫羊霍苷及其肠菌代谢产物对THP-1细胞分泌细胞因子的影响。药学学报 35:245-248, 2,000。
• Gao, X. Fei, B. Wang, J. Zhang, M. Minami, T. Nagata and T. Ikejima. Effects of polysaccharides (FI0-b) from mycelium of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (I). Acta Pharmacol. Sinica　21(12):1179-1185, 2,000.
• X. Gao, X. B. Wang, Fei, J. Zhang, M. Minami, T. Nagata and T. Ikejima. Effects of polysaccharides (FI0-c) from mycelium of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (II). Acta Pharmacol. Sinica　 21(12):1186-1192, 2,000
• Y. Wang, B. Wang, T. Liu, M. Minami, T. Nagata and T. Ikejima. Metabolism of Ginsenoside Rg1 by intestinal bacteria II. Immunological activity of Ginsenoside Rg1 and Rh1. Acta Pharmacol. Sinica 21(9):792-796, 2,000.
• Y. Sako, M. Nakao, T. Ikejima, ZX. Piao, K. Nakaya and A. Ito. Molecular characterization and diagnostic value of Taenia solium low-molecular-weight antigen genes. J. Clin. Microbiol. 38(12): 4439-4444, 2,000.
• 郭颖杰，费晓方，朴志贤，刘永强，王本祥，池岛乔，黄芪水煎剂对黑色瘤细胞A375-S2的杀伤作用。中草药 31：114-116，2000。
• Y.J. Guo, T. Matsumoto, Y. Kikuchi , T. Ikejima, B.X. Wang and H. Yamada. Effects of a pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. on interleukin 6 production of murine B cells and B cell lines. Immunopharmacol.49:307-316, 2,000.
• 池岛乔、费晓方、郭颖杰、刑德君、王本祥、田代真一。吴茱萸碱对凋亡的诱导 日本未病系统学会杂志7(1):10-11、2001.
• 池岛乔、李阳芳、滕玉欧、张洁、王本祥、田代真一。由中药精制多糖引起炎症细胞因子的双向调节 日本未病系统学会杂志7(1):125-126、2001.
• 朴志贤、郭颖杰、王本祥、刘彬、池岛乔，中药养血活血复方对炎症细胞因子产生的影响 日本未病系统学会杂志7(1):127-128、2001。
• Saren-Tuoya, Wang Fuchun, Wang Benxiang, Takashi Ikejima. Effect of acupuncture on TNFa gene expression in the rat of experimental osteoporosis. The International Journal of Acupuncture 6 (2): 46-50, 2001.
• D. Mei, X. Feng, B. Wang, L. Wu and T. Ikejima. Two new steroidal saponins from the rhizomes of Dioscorea panthaica and their cytotoxic activity. Planta Med. 67:1-5, 2,001.
• D. Mei, X. Feng, B Wang, L Wu and T. Ikejima. Two novel frostanol saponins from rhizomes of Dioscorea panthaica. Prain et Burkill and their cytotoxic activity. Tetrahedron 57:501-506, 2,001.
• Gong Yujing, Fei Xiaofang, Gao Xiaoxia, Zhang Jie, Wang Benxiang, Mutsuhiko Minami, Toshi Nagata and Takashi Ikejiama. Effect of polysaccharide FIII-2 and Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human periferal blood mononuclear cells. Chin J PharmacolToxicol 15(6):401-407, 2,001.
• 池岛乔.　灵芝多糖对炎症性细胞因子产生的双向调节作用。 日中医学　16(1): 20-21，2,001。
• L. Wen, QL. Zhou, T. Ikejima and BX. Wang. New polypeptide promoting epidermal cell and chondrocyte proliferation from Cervus elaphus Linuaeus. Acta Pharmaceutica Sinica 36(18):913-916, 2,002.
• L. Wen, QL. Zhou, T. Ikejima. And BX. Wang.　 Novel polypeptide from Cervus elaphus Linuaeus. Chinese Chemical Letter 13(1):147-150, 2,002.
• XF. Fei, BX, Wang, S. Tashiro, TJ. Li, JS. Ma and T. Ikejima. Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells. Acta Pharmacol. Sinica 23(4):315-322, 2002.
• 费晓方，王本祥，池岛乔， 吴茱萸碱诱导人子宫劲癌HeLa细胞凋亡的机制研究。药理学报 37（9）：673-676，2,002。
• Yang-Fang Li, Yu-Ou Teng, Jie Zhang, Ben-Xiang Wang and Takashi Ikejima. Effects of natural polysaccharides from Tremella fuciformis Berk, Panax ginseng C. A. Meyer, Saccharomyces cerevisiae and Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells.　日本未病系统学会杂志　8(1):12-18, 2,002.
• 张春玲，吴立军，田代真一，小野寺敏，池岛乔。冬凌草甲素通过激活caspase 诱导HeLa细胞凋亡。中国药理学通报, 19(5):521-525, 2003。
• 张莹，吴立军，田代真一，小野寺敏，池岛乔。 吴茱萸碱诱导人黑色素瘤A375-S2细胞的两种死亡机制。药学学报38(9):650-653, 2003。
• XF. Fei, BX. Wang, TJ. Li, S. Tashiro and T. Ikejima. Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells. Cancer Science 94(1):92-98, 2003.
• Wang Ben-Xiang, Zhou Qiu-Li, Yang Ming, Wang Yan, Cui Zhi-Yong, Liu Yong-Qiang, Ikejima Takashi. Hypoglymemic mechanism of ginseng glycopeptide. Acta Pharmacol Sin 24 (1):61-66, 2003.
• FEI Xiao-fang, Zheng Ke-yan, Wang Ben-xiang, TASHIRO Shinichi and IKEJIMA Takashi. Ginsenoside Rh2 showing ability to induce apoptosis in HeLa cells. Chem Res Chinese U 19(1):49-53, 2003.
• 张春玲，吴立军，田代真一，小野寺敏，池岛乔。冬凌草甲素通过激活caspase 诱导HeLa细胞凋亡。中国药理学通报, 19(5):521-525, 2003。
• 张莹，吴立军，田代真一，小野寺敏，池岛乔。 吴茱萸碱诱导人黑色素瘤A375-S2细胞的两种死亡机制。药学学报38(9):650-653, 2003。
• 霍锐，周秋丽，王本祥，王敏伟，田代真一，小野寺敏，池岛乔。薯蓣苷元诱导人黑色瘤细胞A375-S2凋亡依赖caspase和MAPK途径。中国药理学与毒理学杂志，17:270-275, 2003.
• XF. Fei, BX. Wang, TJ. Li, S. Tashiro and T. Ikejima. Evodiamine, a constituent of Evodiae Fructus, induces anti-priliferating effects in tumor cells. Pre Symptomatic Medicine and Anti-Aging 12(1):120-126, 2003.
• 10 A. Ito, H. Yamasaki, M. Nakao, Y. Sako, M. Okamoto, M.O. Sato, K. Nakaya, S. S. Margono, T. Ikejima, A.A. Kassuku, S. M. S. Afonso, W. B. Ortiz, A. Plancarte, A. Zoli, S. Geerts, and P. S. Craig. Multiple genotypes of Taenia solium-ramifications for control. Acta Tropica 87(1):95-101, 2003.
• Tsukasa Matsumoto, Ying-Jie Guo, Takashi Ikejima, Haruki Yamada. Induction of cell cycle regulatory proteins by murine B cell proliferating pectic polysaccharide from the roots of Bupleurum falcatum L. Immunology Letters, 89:111-118, 2003.
• Ying Zhang, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Intracellular regulation of evodiamine-induced A375-S2 cell death. Biol Pharm Bull, 26(11):1543-1547, 2003.
• 池岛乔，安巍巍，王敏伟。去甲班蝥素通过caspase, MAPK和线粒体途径诱导HeLa细胞凋亡。中国病理生理杂志, 19(11):1444, 2003。
• Ying Zhang, Qi-Hui Zhang, Li-Jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima . Atypical apoptosis in L929 cells induced by Evodiamine isolated from Evodia rutaecarpus. J Asian Natur Product Res 6(1):17-27, 2004.
• 张莹，张起辉，吴立军，田代真一，小野寺敏，池岛乔。 吴茱萸碱诱导人宫颈癌HeLa细胞凋亡过程中非caspase调控因子。中国药理学通报 20(1):61-64, 2004。
• Y. Zhang, L. Wu, S. Tashiro, S. Onodera, and T. Ikejima. Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis. Acta Pharmacol Sin 25(1):83-89, 2004.
• Chunling Zhang, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Oridonin induced A375-S2 cell apoptsis via Bax-regulated caspase pathway activation, dependent of cytochrome c/caspase-9 apoptosome. J Asian Natur Product Res 6(2):127-138, 2004.
• Chun-ling Zhang, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Oridonin induces apoptosis in human cervical carcinoma HeLa cells through caspase-3/ICAD pathway after altered expression of Bcl-2/Bax. Acta Pharmacol Sin, 25 (5): 691-698, 2004.
• 张春玲，吴立军，左海军，田代真一，小野寺敏，池岛乔。冬凌草甲素通过线粒体途径诱导A375-S2细胞凋亡。中草药, 35 (4): 423-426, 2004。
• Zhen Wu, Li-jun Wu, Lin-hao Li, Shin-ichi Tashro, Satoshi Onodera, Takashi Ikejima. Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis. J Asian Natur Product Res, 6 (3): 155-166, 2004.
• Dong Wang, Mingyu Xia, Zheng Cui, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Cytotoxic effects of mansonone E and F isolated from Ulmus pumila. Biol Pharm Bull, 27(7): 1025-1030, 2004.
• Linhao Li, Lijun Wu, Humiaki Uchiumi, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Silymarin prevents ultraviolet light-induced A375-S2 cell apoptosis by inhibition of caspase-9, 3 pathway after expression of Bcl-XL and activation of ERK/MAPK pathway. Biol Pharm Bull, 27(7):1031-1036, 2004.
• 张春玲，吴立军，左海军，田代真一，小野寺敏，池岛乔。冬凌草甲素通过改变Bax/Bcl-xL表达激活caspase-3诱导A375-S2细胞凋亡。中国药理学通报 20 (6): 669-672, 2004。
• Dong M, Feng XZ, Wang BX, Ikejima T, Wu LJ. Steroidal saponins from Dioscorea panthaica and their cytotoxic activity. Pharmazie 59(4): 294-296, 2004.
• 夏明钰，王敏伟，王浩然，田代真一，小野寺敏，池岛乔。血竭素高氯酸盐诱导人宫劲癌HeLa细胞凋亡的机制。药学学报，39 (12): 966-970, 2004。
• Mingyu Xia, Minwei Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species. J Pharmacol Sci 95: 273-284, 2004.
• 张莹，张起辉，吴立军，田代真一，小野寺敏，池岛乔。吴茱萸碱在诱导小鼠纤维肉瘤L929细胞凋亡过程中对细胞周期的阻滞作用。中国中西医结合杂志24: 169-172, 2004.
• Dong M, Feng X, Wang BX, Ikejima T, Wu LJ. Microbial metabolism of pseudoprotodioscin. Planta Med 70 (7): 637-641, 2004.
• 王澈，王敏伟，田代真一，小野寺敏，池岛乔。人白细胞介素1 b (IL-1b)诱导人黑色素瘤A375-S2细胞凋亡的机制。中国病理生理杂志 20 (7): 1138-1143, 2004。
• 萨仁，王富春，池岛乔。针灸治疗实验性骨质疏松症对肿瘤坏死因子基因表达的影响。针刺研究 29 (2): 140-144, 2004.
• Rui Huo, Qiu-Li Zhou, Ben-Xiang Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Diosgenin induces apoptosis in HeLa cells via activation of caspase pathway. Acta Pharmacol Sinica 25 (80): 1077-1082, 2004.
• Wei-Wei An, Min-Wei Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Norcantharidin induces human melanoma A375-S2 cell apoptosis through mitochondrial and caspase pathways. Journal of Korea Medical Science 19 (4): 560-566, 2004.
• Chun-Ling Zhang, Li-Jun Wu, Hai-Jun Zuo, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent of p53 and ERK activation. J Pharmacol Sci, 96:155-163, 2004.
• Weiwei An, Xiang-fong Gong, Min-wei Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Norcantharidin induces apoptosis in HeLa cells through caspase, MAPK and mitochonderial pathways. Acta Pharmcol Sin, 25 (11): 1502-1508, 2004.
• Xianfeng Gong, Minwei Wang, Zhen Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells. Experimental and Molecular Medicine, 36(6): 55-57, 2004.
• 张莹，张起辉，吴立军，田代真一，小野寺敏，池岛乔。吴茱萸碱诱导A375-S2细胞死亡过程中对ERK激酶的调控。中国病理生理杂志 20(12):2175-2179, 2004.
• 龚显峰，王敏伟，田代真一，小野寺敏，池岛乔。 土槿皮乙酸体外诱导A375-S2细胞凋亡。中国中药杂志30 (1):24-26, 2005。
• 安巍巍，薛莲，王敏伟，田代真一，小野寺敏，池岛乔。去甲班蝥素诱导小鼠肺纤维瘤L929细胞凋亡。中国癌症杂志15 (1): 22-25, 2005。
• Wei-wei An, Minwei Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. MAPK-dependent apoptosis in norcantharidin-treated A375-S2 cells is proceeded by the activation of protein kinase C. Chin Med J, 118(3): 198-203, 2005.
• Mingyu Xia, Minwei Wang, Shin-ichi Tashiro, Satoshi Onodera, Mutsuhiko Minami, Takashi Ikejima. Dracordin perchlorate induces A375-S2 cell apoptosis via accumulation of p53 and activation of caspases. Biological & Pharmaceutical Bulletin, 28 (2): 226-232, 2005.
• Xiu Li Bi, Jing Yu Yang, Ying Xu Dong, Ji Ming Wang, Yong Hong Cui, Takashi Ikejima, Yu Qing Zhao, Chun Fu Wu. Resveratrol inhibits nitric oxide and TNF-a production by lipopolysaccharide-activated microgria. International Immunopharmacology 5:185-193, 2005.
• Xian-Feng Gong, Min-Wei Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells. Archives of Pharmacal Research, 28(1):68-72, 2005.
• Yan-Qiu Liu, Song You, Chun-Ling Zhang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Oridonin enhances phagocytosis of UV-irradiated apoptotic U937 cells by macrophages. Biological & Pharmaceutical Bulletin, 28 (3):401-407, 2005.
• 吴振，吴立军，田代真一，小野寺敏，池岛乔。紫草素诱导A375-S2细胞凋亡的分子机制研究。 中国药理学通报 21 (2):202-205, 2005。
• 龚显峰，王敏伟，吴振，田代真一，小野寺敏，池岛乔。 土槿皮乙酸体外诱导HeLa细胞凋亡。中国药学杂志40 (8):264-266, 2005。
• 夏明钰，王敏伟，田代真一，池岛乔。 厚朴酚通过改变Bax/Bcl-XL表达和激活caspase诱导人宫劲癌HeLa细胞凋亡。中国药理学通报，21(3):318-322, 2005。
• Shen Y, Ichino M, Nakazawa M, Ikejima T, Kojima Y, Okuda K, Minami M. Therapeutic effect of CpG-enriched plasmid administration on the tight-skin mouse model of scleroderma. J Autoimmun 24(3):183-190.
• 安巍巍，王敏伟，龚显峰，田代真一，小野寺敏，池岛乔。去甲斑蝥素通过半胱胺酸天冬酶诱导HeLa细胞凋亡。中国病理生理杂志, 21(3):417-421, 2005。
• Che Wang, Min-wei Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Roles of SIRT1 and phosphoinositide-3-OH kinase (PI3K)/protein kinase C (PKC) pathways in evodiamine-induced A375-S2 human melanoma cell death. J Pharmacol Sci, 97:494-500, 2005.
• 安巍巍，龚显峰，王敏伟，田代真一，小野寺敏，池岛乔。去甲斑蝥素诱导人黑色瘤A375-S2细胞凋亡。中国医院药学杂志， 25(6):501-504, 2005。
• Huang Qing, Wu Li-Jun, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. HeLa cell cycle was arrested on G0/G1 phase by silymarin in serum-free medium. Chinese Journal of Clinical Rehabilitation, 9(6):242-243, 2005.
• Che Wang, Min-wei Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Evodiamine induced human melanoma A375-S2 cell death partially through interleukin 1-mediated pathway. Biological & Pharmaceutical Bulletin, 28(6):984-989, 2005.
• Tsukasa Matsumoto, Hosono-Nishiyama K, Ying-Jie Guo, Takashi Ikejima, Haruki Yamada. A possible signal transduction pathway for cyclin D2 expression by a pectic polysaccharide from the roots of Bupleum falcatum L. in murine B cell. Int Immunopharmacol 5(9):1373-1386, 2005.
• Hong Cao, Min-Wei Wang, Li-Xin Sun, Takashi Ikejima, Zhi-Qing Hu, Wei-Hua Zhao. Pharmacodynamic comparison of pantoprazole enantiomers: inhibition of acid-related lesions and acid secretion in rats and guinea pigs. J Pharm Pharmacol 57(7):923-927, 2005.
• 王澈，王敏伟，田代真一，小野寺敏，池岛乔。 人白细胞介素1b通过线粒体激活caspase-3诱导A375-S2细胞凋亡。免疫学杂志, 21(5):403-405, 2005.
• Zhen Wu, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Phosphorylated ERK up-regulated p53 expression in shikonin-induced HeLa cell apoptosis. Chin Med J 118(8):671-677, 2005.
• Qing Huang, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. (+)-Catechin, an ingredient of green tea, protects murine microglia from oxidative stress-induced DNA damage and cell cycle arrest. J Pharmacol Sci, 98(1):16-24, 2005.
• Qing Huang, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Lin-hao Li, Takashi Ikejima. Silymarin augments human cervical cancer HeLa cell apoptosis via p38/JNK MAPK pathways in serum-free medium. J Asian Natur Product Res, 7(5):701-709, 2005.
• Yanqiu Liu, Song You, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Activation of phosphoinositide 3-kinase, protein kinase C and extracellilar signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells. J Pharmacol Sci, 98:361-371, July 29, 2005.
• 龚显峰，王敏伟，池岛乔。辣椒素诱导A375-S2细胞的凋亡。中华肿瘤杂志 27(7), 401-403, 2005。
• Che Wang, Min-wei Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. IL-1b acts in synergy with endogenous IL-1b in A375-S2 human melanoma cell apoptosis through mitochondrial pathway. J Korean Med Sci, 20(4):555-561, 2005.
• Jian Huang, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Bcl-2 Up-regulation and P-p53 Down-regulation Account for the Low Sensitivity of Murine L929 Fibrosarcoma Cells to Oridonin-Induced Apoptosis. Biological & Pharmaceutical Bulletin, 28(11), 2068-2074, 2005.
• 王澈，王敏伟，田代真一，小野寺敏，池岛乔。蛋白激酶C在吴茱萸碱诱导的人黑色瘤A375-S2细胞死亡中的作用。药学学报, 40(11):1033-1036 , 2005.
• T. Ikejima, Z. Piao, M. O. Sato, Y. Sako, S. Bao, R. Si, F. Yu, C. Zhang, M. Nakao, H. Yamasaki, K. Nakaya, T. Kanazawa, A. Ito. Evaluation of clinical and serological data of Taenia solium cysticercosis in Eastern area of Inner Mongolia Autonomous Region, China. Trans R Soc Trop Med Hyg 99(8): 625-630, 2005.
• 黄晴，吴立军，路平，田代真一，小野寺敏，池岛乔。 儿茶素对tBHP诱导的N9细胞DNA损伤的保护作用。中国药理学通报， 21(12): 1520-1523, 2005.
• 王澈，王敏伟，田代真一，小野寺敏，池岛乔。吴茱萸碱部分通过人白介素1所介导的途径诱导人黑色素A375-S2细胞死亡。中国药理学通报，21(12): 1478-1481, 2005。
• Jian Huang, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. The augmentation of TNFa-induced cell death in murine L929 fibrosarcoma by the pan-caspase inhibitor z-VAD-fmk through pre-mitochondrial- and MAPK-dependent pathways. Acta Medica Okayama, 59(6):253-260, 2005.
• Jian Huang, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. A comparison of the signal pathways between the TNFa -and oridonin-induced murine L929 fibrosarcoma cell death. Acta Medica Okayama, 59(6):261-270, 2005.
• 刘艳秋，游松，田代真一，小野寺敏，池岛乔。冬凌草甲素增强U937细胞吞噬凋亡小体过程中ERK途径的调节作用。中国药理学通报, 22(1):841-844, 2006。
• Lin-hao Li, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Fumiaki Uchiumi,Takashi Ikejima. The roles of Akt and MAPK family members in ailymarin's protection against UV-induced A375-S2 cell apoptosis. International Immunopharmacology, 6(2): 190-197, 2006.
• Yanqiu Liu, Song You, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Roles of Ras and ecxtracellular signal-regulated kinase-dependent NF-kB activation in oridonin-enhanced phagocyosi of apoptotic cells by human macrophage-like U937 cells. International Pharmacology, 6(2): 260-268, 2006.
• 刘艳秋，游松，张春玲，田代真一，小野寺敏，池岛乔。 冬凌草甲素增强巨噬细胞对U937细胞凋亡的吞噬作用。中国病理生理杂志, 22(2), 209-213, 2006.
• 黄键，吴立军，田代真一，小野寺敏，池岛乔。Oridonin部分通过TNFa信转导途径诱导L929细胞凋亡。中国药理学通报，22(4): 471-475, 2006。
• Qing Huang, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Elevated levels of DNA repair enzymes and antioxidative enzymes by (+)-catechin in murine microglia cells after oxidative stress. J Asian Natur Product Res, 8:61-71, 2006.
• Mingyu Xia, Minwei Wang, Shin-ichi Tashiro, Satoshi Onodera, Mutsuhiko Minami, Takashi Ikejima. Dracorhodin perchlorate induces apoptosis in HL-60 cells. J Asian Natur Product Res, 8(4):335-343, 2006.
• Qiao Cui, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Augmentation of oridonin-induced apoptosis observed with reduced autophagy. Journal of Pharmacological Sciences, 101(3):230-239, 2006.
• Xiangfeng Gong, Minwei Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death. Experimental and Molecular Medicine, 38(4):428-434, 2006.
• 杨小珂，李林昊，周蓓，吴立军，田代真一，小野寺敏，池岛乔。水飞蓟素和Fas激动性抗体，CH11，共同作用诱导A375-S2细胞凋亡。中国药理通报，1242-1245, 2006。
• Bei Zhou, Li-Jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Fumiaki Uchiumi, Takashi Ikejima. Silibinin protects rat cardiac myocyte from isoproterenol-induced DNA damage independent on regulation of cell cycle. Biological & Pharmaceutical Bulletin, 29(9):1900-1905, 2006.
• Yan-Qiu Liu, Song You, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Fas/FasL signaling allows extracellular-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells. Biological & Pharmaceutical Bulletin, 29(9):1873-1879, 2006.
• Ai-min Qiao, Takashi Ikejima, Shin-ichi Tashiro, Satoshi Onodera, Wei-ge Zhang, Ying-liang Wu. Involvement of mitochondria and caspase pathways in N-demethyl-clarithromycin induced apoptosis in human cervical cancer HeLa cell. Acta Pharmacol Sin, 27(12):1622-1629, 2006.
• Jian Huang, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Fibroblast growth factor-2 suppress oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway. J. Pharmacol Sci., 102:305-313, 2006.
• Lin-hao Li, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Fumiaki Uchiumi, Takashi Ikejima. Silybinin prevents UV-induced HaCaT cell apoptosis partly through inhibition of caspase-8 pathway. Biological & Pharmaceutical Bulletin, 29(6):1096-1101, 2006.
• Bei Zhou, Li-Jun Wu, Lin-Hao Li, Shin-ichi Tashiro, Satoshi Onodera, Fumiaki Uchiumi, Takashi Ikejima. Silibinin protects against sisoproterenol-induced rat cardiac myocyte injury through motochondrial pathway after up-regulation of SIRT1. J. Pharmacol Sci. 102(4):387-395, 2006.
• 崔侨，田代真一，小野寺敏，池岛乔。冬凌草甲素通过诱导人宫颈癌HeLa细胞自噬下调凋亡的机制。药学学报，42(1):35-39, 2007。
• Dan Li, Lijun Wu, Shin-ichi Tashiro,　Satoshi Onodera, Takashi Ikejima. Oridonin inhibited tyrosine kinase activity and induced apoptosis in human epidermoid carcinoma A431 cells. Biological & Pharmaceutical Bulletin, 3092):254-260, 2007.
• 周蓓，吴立军，田代真一，小野寺敏，内海文彰，池岛乔。水飞蓟宾对异丙肾上腺素引起的大鼠乳鼠心肌细胞损伤的保护作用及其机制。药学学报，42(3):263-268, 2007。
• Dan Li, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Oridonin induced A431 cell apoptosis partially through blockage of Ras/Raf/ERK signal pathway. J Pharmacol Sci, 103(1):56-66, 2007.
• 李林昊，吴立军，田代真一，小野寺敏，内海文彰，池岛乔。水飞蓟素在紫外线照射诱导A375-S2细胞凋亡中发挥抑制作用。中国病理生理杂志，in press, 2007。
• Lin-hao Li, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Fumiami Uchiumi, Takashi Ikejima. Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin’s protection against UV-induced A375-S2 cell apoptosis. J Asian Natur Product Res, in press, 2007.
• Lin-hao Li, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Fumiami Uchiumi, Takashi Ikejima. Silymarin enhanced cytotoxic effect of anti-Fas agonistic antibody CH11 on A375-S2 cells. J Asian Natur Product Res, in press, 2007.
• 乔爱敏，池岛乔，张为革，吴英良。AKT和ERK激活对N-去甲基克拉霉素诱导的HeLa细胞凋亡起保护作用。中国药理学通报，in press, 2007.
• Bei Zhou, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Fumiaki Uchiumi, Takashi Ikejima. Activation of extracellular signal-regulated kinase during silibinin-protected isoproterenol-induced apoptosis in rat cardiac myocyte is tyrosine kinase pathway-mediated and protein kinase C-dependent Acta Pharmacol Sin, in press, 2007.
• Dan Li, Lijun Wu, Shin-ichi Tashiro,　Satoshi Onodera, Takashi Ikejima. Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway. J Asian Natur Product Res, in press, 2007.
• Qiao Cui, Shin-ichi Tashiro, Satoshi Onodera, Mutsuhiko Minami, Takashi Ikejima. Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biological & Pharmaceutical Bulletin, in press, 2007.

会议发表（2002年以后）

• 池岛乔、吴立军、王敏伟、小野寺敏、田代真一。中国天然药物中精制的化合物引起肿瘤细胞死亡。第二届日本临床中医药学会、纪念演讲。东京、日本、2002。
• 池岛乔。吴立军、王敏伟、小野寺敏、田代真一。以中国天然药物为主的单体化合物诱导肿瘤细胞死亡。21世纪人类与健康论坛、哈尔滨、中国、2002。
• 池岛乔。Evodiamine induces tumor cells through different pathways: apoptosis and necrosis. 中华医学会 · 日本医学会合同总会、北京、中国、2002。
• 池岛乔。吴立军、王敏伟、小野寺敏、田代真一。以中国天然药物为主的单体化合物诱导肿瘤细胞死亡。北京大学医学部研讨会、北京、中国、2002。
• 池岛乔。中国天然药物吴茱萸碱单体化合物的抗癌作用。哈尔滨医科大学生活习惯病讲座。哈尔滨、中国、2003。
• 池岛乔，黄晴，李林昊，周蓓。水飞蓟素（silymarin）在不同条件下对细胞凋亡发挥双向作用。哈尔滨医科大学生活习惯病研讨会。哈尔滨，中国，2004。
• 池岛乔、夏明钰。血褐素类似物质、dracorhodin　perchlorate血褐素高氯酸盐对肿瘤细胞凋亡的诱导。第三届日本临床中医药学会学术集会、三岛、日本、2003。
• 池岛乔、刘艳秋、张春玲。肿瘤细胞机制研究死亡的。北京大学研讨会。北京、中国、2004。
• Chun-ling Zhang，Li-jun Wu，Shin-ichi Tashiro，Satoshi Onodera，Takashi Ikejima。Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929. The Fifth International Symposium on Natural Medicine, Shenyang, China, 2004。
• Qing Huang，Li-jun Wu，Shin-ichi Tashiro，Satoshi Onodera，Takashi Ikejima。The inhibition effects of (+)-catechin an tBHP-induced N9 cell apoptosis and cell cycle arrest. The Fifth International Symposium on Natural Medicine, Shenyang, China, 2004。
• Lin-hao Li，Li-jun Wu，Bei Zhou，Zhen Wu，Shin-ichi Tashiro，Satoshi Onodera，Fumiaki Uchiumi，Takashi Ikejima。Silymarin prevents UV-irradiate A375-S2 cell apoptosis. The Fifth International Symposium on Natural Medicine, Shenyang, China, 2004。
• Yan-qiu Liu，Song You，Chun-ling Zhang，Shin-ichi Tashiro，Satoshi Onodera，Takashi Ikejima。Oridonin induces U937 cell death at high doses and enhances phagocytosis of apoptotic U937 cells by macrophage-like cells at low doses. The Fifth International Symposium on Natural Medicine, Shenyang, China, 2004。
• 46.Che Wang，Min-wei Wang，Shin-ichi Tashiro，Satoshi Onodera，Ying Zhang，Takashi Ikejima。Evodiamine-induced apoptosis in human melanoma A375-S2 cells partially goes through IL-1b-induced apoptosis pathway. The Fifth International Symposium on Natural Medicine, Shenyang, China, 2004。
• 池岛乔。冬凌草甲素对癌细胞的死亡和吞噬凋亡死的癌细胞的影响。哈尔滨医科大学中药现代化研讨会。哈尔滨，中国，2004。
• 池岛乔、李林昊、周蓓。由紫外线照射引起的人黑色素瘤A375-S2细胞周期阻滞与水飞蓟素的抑制作用。第四届日本临床中医学会。东京、日本、2004。
• 池岛乔。冬凌草甲素对癌细胞的死亡和吞噬凋亡死的癌细胞的影响。吉林大学生命科学研究院研讨会，长春，中国，2004。
• Takshi Ikejima, Lin-hao Li, Bei Zhou, Li-jun Wu. A375-S2 cell cycle arrest and apoptosis induced by UV irradiation were inhibited by silymarin.10th International Kyunghee East-West Pharmaceutical Synpojium on Natural Product Application, Seoul, Korea, 2004.
• Takashi Ikejima, Zhixian Piao, Yasuhito Sako, Maecello O. Sato, Siqin Bao, Rina Si, Fulan Yu, Chunling Zhang, Minoru Nakao, Hiroshi Yamasaki, Kazuhiro Nakaya, Tamotsu Kanazawa, Akira Ito. Evaluation of clinical and serological data of Taenia solium cysticercosis patients in Eastern Area of Inner Mongolia, China. Taeniasis/Cysticercosis and Echinococcosis International Symposium with Focus on Asia and the Pacific and The Third Congress of Federation of Asian Parasitologists focused on Cestode Zoonosis, Asahikawa, Japan, 2005.
• Takashi Ikejima, Che Wang, Jia Yang. Evodiamine induced human melanoma A375-S2 cell death partially through interleukin 1 mediated pathway. China-Russia International Conference on Pharmacology, Harbin, China, 2005.
• Takashi Ikejima, Lin-hao Li, Qing Huang, Bei Zhou.A375-S2 cell cycle arrest and apoptosis induced by UV irradiation were inhibited by silymarin. The 4th International Congress for Chinese Medicine, Kawasaki, Japan, 2005.
• Lin Hao Li, Takashi Ikejima. Silymarin preventys UV-induced HaCaT cell apoptosis. 4th Shenyang Nagoya Nanjing Pharmaceutical Science Symposium, Shenyang, China, 2005.
• Jia Yang, Che Wang, Takashi Ikejima. Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death. 4th Shenyang Nagoya Nanjing Pharmaceutical Science Symposium, Shenyang, China, 2005.
• Yan-Qiu Liu, Song You, Takashi Ikejima.　Roles of extracellular signal-regulated kinase in oridonin enhanced-phagocytosis of apoptotic cells and induced-apoptosis in human histocytic lymphoma U937 cells. 4th Shenyang Nagoya Nanjing Pharmaceutical Science Symposium, Shenyang, China, 2005.
• Jian Huang, Lijun Wu, Takashi Ikejima. The low sensititity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis is Bcl-2- and P-p53-dependent. 4th Shenyang Nagoya Nanjing Pharmaceutical Science Symposium, Shenyang, China, 2005.
• Bei Zhou, Takashi Ikejima. The mechanism of silymarine’s protective effect against injury to cardiac myocytes. 4th Shenyang Nagoya Nanjing Pharmaceutical Science Symposium, Shenyang, China, 2005.
• Qing Huang, Lijun Wu, Takashi Ikejima. The protective effect of (+)-catechin on mitochondria in murine microglia cells. 4th Shenyang Nagoya Nanjing Pharmaceutical Science Symposium, Shenyang, China, 2005.
• 池岛乔、王澈、田代真一、小野寺敏。吴茱萸碱诱导人黑色素瘤A375-S2细胞凋亡与IL-1信号传导途径的关系。第二十二届日本和汉医药学会。 东京， 2005。
• 池岛乔、刘艳秋、田代真一、小野寺敏。Oridonin 引起人巨噬样U937细胞的凋亡小体吞噬作用增强中PI3K、PKC及ERK　MAPK 的参与。第五届日本临床中医药学会学术集会。　川崎市、日本、2005。
• 池岛乔、崔侨、田代真一、小野寺敏。冬凌草甲素通过诱导人宫颈癌HeLa细胞自噬下调凋亡的机制。第六届日本临床中医药学会学术集会。　东京、日本、2006。