毛世瑞

姓名：毛世瑞
职称：副教授，硕士生导师
现通讯地址：沈阳药科大学药剂教研室
e-mail: maoshirui@vip.sina.com

教育背景:
2002-2004 Institute of Pharmaceutics and Biopharmacy 博士学位
Phillips University of Marburg，Germany
1991-1994 沈阳药科大学药剂学专业 硕士学位
1987-1991 沈阳药科大学医药企业管理专业 学士学位

工作经历：
2005.2-2006.4 Department of Pharmaceutics and Biopharmacy, Phillips University of Marburg, Germany博士后

1994.9-2001.7 沈阳药科大学药剂教研室

社会兼职：

1. 中国医学研究编委
2. 以下杂志的特约审稿人:

Jouranl of Controlled Release
Pharmaceutical Research
Drug Dev Ind Pharm
Journal of Drug Delivery Science and Technology

主要研究领域：生物可降解高分子聚合物作为基因和蛋白类药物载体的研究，聚电解质复合物作为药物载体的研究，黏膜给药系统，生物可降解微球，固体脂质纳米粒, 微乳，缓控释制剂，药物新剂型，药物稳定性等.

著作：

1. CHITOSAN COPOLYMERS FOR INTRANASAL DELIVERY OF INSULIN, Der ander Verlag, Germany, 2004. 11. 作者。

2. 面向21世纪课程教材《药剂学》 参编 中国医药科技出版, 2002. 8

1. 药剂学实验讲义 参编（第二） 沈阳药科大学 2000.8 全校通用
2. 翻译 “ Pharmaceutical Powder Compaction Technology” Volume 71, edited by Goran Alderborn and Christer Nystrom. 第16，17章。 待出版。
3. 参编《透皮吸收制剂》,待出版。

已发表论文
到目前为止，已在国内外期刊杂志及国内外学术会议上发表学术论文50余篇，代表性作品如下：

1. Mao Shirui, Bakowsky Udo, Jintapattanakit Anchalee, Kissel Thomas. Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin. J Pharm Sci 2006, 95(5), 1036-48.
2. Mao Shirui, Neu Michael, Germershaus Oliver, Kissel Thomas. Physicochemical and biological characterization of polyethylenimine-graft-poly(ethylene glycol) block copolymers as carriers of siRNA. CRS Meeting in Jena, February 2006, Germany.
3. Mao Shirui, Xu Jing, Cai Cuifang, Germershaus Oliver, Schaper Andreas, Kissel Thomas. Influence of process parameters on the internal morphology of FITC-dextran loaded PLGA microspheres. CRS Meeting in Jena, February 2006, Germany.
4. Oliver Germershaus, Shirui Mao and Thomas Kissel. Comparative studies of kinetics and cellular uptake mechanism of chitosan, trimethyl chitosan and peylated trimethyl chitosan-pDNA complexes in a cell line of pulmonary epithelium A549. CRS Meeting in Jena, February 2006, Germany.
5. Jintapattanakit Anchalee, Mao Shirui, Junyaprasert Varaporn, Kissel Thomas. A comparative study between surface modified chitosan insulin nanocomplexes and nanoparticles: Proof of oral delivery concept. CRS Meeting in Jena, February 2006, Germany.
6. Mao Shirui, Yang Shiling, Bi Dianzhou. Pharmacodynamics and potential toxicity of intranasally administrated dipyrone. Biol. Pharm. Bull 2006 (in press).
7. Mao Shirui, Shuai Xintao, Unger Florian, Wittmar Matthias Xiulan Xie and Kissel Thomas. Synthesis, characterization and cytotoxicity of poly (ethylene glycol)-graft-trimethyl chitosan block copolymers, Biomaterials. 2005,26(32), 6343-6356.
8. Mao Shirui, Germershaus Oliver, Fischer Dagmar, Linn Thomas, Schnepf Robert, Kissel Thomas. Uptake and transport of self-assembled PEGylated trimethyl chitosan block copolymer-insulin nanocomplexes in Caco-2 cell monolayers, Pharm. Res. 2005, 22(12), 2058-2068.
9. Mao Shirui, Wang Pu, Bi Dianzhou. Investigations on 5-Fu solid lipid nanoparticles prepared by hot homogenization, Die Pharmazie 2005,60(4), 273-277.
10. Germershaus Oliver, Mao Shirui, Jintapattanakit Anchalee, Kissel Thomas. Pegylated quarternized chitosan as novel gene delivery vector. Controlled Release Society 32nd Annual Meeting & Exposition TRANSACTIONS, July 2005, Miami, USA.
11. Wang Yanzhi, Deng Yihui, Mao Shirui, Jin Shengxuan, Wangjian, Bi Dianzhou. Characterization and Body Distribution of beta-Elemene Solid Lipid Nanoparticles (SLN). Drug Dev Ind Pharm.2005, 31(8), 769-778.
12. Mao Shirui, Zhang Lei, LI Ming, BI Bo, BI Dianzhou. Formulation and characterization of water-in-oil nanoemulsion of salbutamol sulfate for peroral administration. Journal of Shenyang Pharmaceutical University 2005,22(6), 401-404.
13. Germershaus Oliver, Mao Shirui, Jintapattanakit Anchalee, Kissel Thomas. Pegylated quarternized chitosan as novel gene delivery vector. CRS Meeting in Marburg, March 2005, Germany.
14. Mao Shirui, Shuai Xintao, Unger Florian, Simon Michael, Bi Dianzhou, and Kissel Thomas. The depolymerization of chitosan: Effects on physicochemical and biological properties, Int J Pharm 2004, 281, 45-54.
15. Mao Shirui, Chen Jianming, Liu Huan, Wei Zhenping, Bi Dianzhou. Intranasal administration of melatonin starch microsphere, Int J Pharm, 2004, 272(1-2), 37-43.
16. Mao Shirui, Liu Huan, Chen Jianming, Wei Zhenping, Bi Dianzhou. Studies on the preparing technique of melatonin starch microspheres for intranasal administration. Journal of Shenyang Pharmaceutical University, 2004, 21(5),324-327.
17. Mao Shirui, Kissel Thomas. Nanocomplex formation between chitosan derivatives and insulin: Effect of pH, polymer structure and molecular weight. CRS Meeting in Heidelberg, April 2004, Germany.
18. Mao Shirui, Ji Hongyu, Bi Dianzhou. The preparation of solid lipid nanoparticles by microemulsion method, Acta Pharmaceutics Sinica, 2003, 38(8), 624-626.
19. Mao Shirui, Liu Jinwei, Bi Dianzhou. Studies on the preparation of acyclovir infusion. Chinese Journal of Pharmaceutical, 2003, 1(4), 137-141.
20. Mao Shirui, Bi Dianzhou. Solid lipid nanoparticles (SLN) as drug delivery system. Journal of Shenyang Pharmaceutical University, 2002,19(6), 455-461.
21. Mao Shirui, Bi Yue, Bi Dianzhou. Studies on preparing technique of nicardipine hydrochloride gelatin microsphere for intranasal administration, Journal of Shenyang Pharmaceutical University, 2002,19(2), 79-82.
22. Mao Shirui, Wang Lei, Cai Cuifang, Bi Dianzhou. Studies on pefloxacin mesylate gel matrix, Journal of Shenyang Pharmaceutical University, 2002,19(1), 9-13.
23. Mao Shirui, Yang Hongtu, Tao Hong, Bi Dianzhou. A study on the stability of the analgin solution, Journal of Shenyang Pharmaceutical University, 2001,17(1), 11-13.
24. Chi Zhiqiang, Mao Shirui, Bi Yue. Factors influencing in vitro drug release of Xanthan Gum as hydrophilic matrix, Journal of Shenyang Pharmaceutical University, 2001,17(1), 8-12.
25. Chen Jianming, Mao Shirui, Bi Dianzhou. Studies on melatonin gelatin microspheres for intranasal administration, Acta Pharmaceutics Sinica, 2000, 35(10), 786-789.
26. Mao Shirui, Yang Hongtu, Bi Dianzhou. Ways of improving nasal drug absorption, Chinese Pharmaceutical Journal, 1998, 33 (11), 641-645.
27. Mao Shirui, Zhou Hui, Bi Dianzhou. Nasal drug delivery and influence factors, Northwest Pharmaceutical Journal, 1997,12(6), 275-278.
28. Mao Shirui, Yang Hongtu, Chen Jianming, Bi Dianzhou. Uses of povidone in pharmaceutics, Journal of Shenyang Pharmaceutical University, 1997,14(3), 224-228.
29. Mao Shirui, Shi Zhe, Bi Dianzhou. Analgin nasal absorption, Chinese Pharmaceutical Journal, 1997,32 (2), 87-91.
30. Mao Shirui, Bi Dianzhou. Determination of analgin content by HPLC, Chinese Journal of Modern Applied Pharmacy, 1997,14(6), 23-25.